Vaccination for dairy animals Sl. No Name of Disease Age at first dose Booster dose Subsequent dose 1 Foot and MouthDisease (FMD) 4 months and above 1 month after first dose Six monthly 2 HaemorrhagicSepticaemia (HS) 6 months and above - Annually in endemic areas. 3 Black Quarter (BQ) 6 months and above - Annually in endemic areas. 4 Brucellosis 4-8 months of age(Only female calves) - Once in a lifetime 5 Theileriosis 3 months of age and above - Once in a lifetime. Only required for crossbred and exotic cattle. 6 Anthrax 4 months and above - Annually in endemic areas. 7 IBR 3 months and above 1 month after first dose Six monthly (vaccine presently not produced in India) 8 Rabies (Post bite therapy only) Immediately after suspected bite. 4th day 7,14,28 and 90 (optional) days after first dose. Source : NDDB Handbook of Good Dairy Husbandry Practices Vaccination schedule for buffaloes Infection Manufacturer Ingredients/adjuvant Dose Primary Booster Revaccination FMD Bovilis®Clovax Intervet India Binary ethyleneimine (BEI) inactivated FMD mineral oil emulsion vaccine containing a mixture of virus serotypes O, A and Asia-1 2ml, i/m (Vial: 100 ml) 3 months onwards I After 4-6 weeks of primary vaccination II After 24 weeks of first booster Every 44-48 weeks after 2nd booster vaccination Raksha Indian Immunologicals Inactivated tissue culture FMD virus strains O, A and Asia-1 adsorbed on Al (OH)3 gel and saponin as an adjuvant 3 ml in the mid-neck region, s/c (Vial: 30 ml) 4 months 2-4 weeks after primary vaccination Every 6 months after booster and every 4 months in endemic areas Raksha Ovac -do- Inactivated tissue culture FMD virus strains O, A, and Asia-1 adjuvanted with mineral oil 2 ml in the mid-neck region, deep i/m 4 months 9 months after primary vaccination Annually Haemorrhagic Septicemia (Galghotu/Ghurrka) Raksha HS Indian Immunologicals Formaldehyde inactivated culture of Pasteurella multocida adsorbed on aluminium hydroxide gel 2 ml, mid-neck region, s/c (Vial:100 ml) 6 months and above Annually and in adverse climatic conditions like unseasonal rains and cyclones, etc. Compound Vaccines of FMD/HS/BQ Raksha biovac (FMD+HS) Indian Immunologicals FMD inactivated antigens against O, A, and Asia-1 strains and formaldehyde inactivated Pasteurella multocida culture mixed together in light mineral oil emulsion 3 ml, midneck, deep i/m (Vial: 30 ml) 4 months 9 months Annually Raksha triovac (FMD+HS+BQ) -do- FMD inactivated antigens against O, A, Asia-1 and formaldehyde inactivated Pasteurella multocida culture, inactivated Clostridium chauvoei culture mixed together in light mineral oil emulsion 3 ml, mid-neck, deep i/m (Vial: 30 ml) 4 months 9 months Annually Raksha HS+BQ -do- Formaldehyde inactivated cultures of Pasteurella multocida and Clostridium chauvoei adsorbed on aluminium hydroxide gel 3 ml, mid-neck region, s/c (Vial: 90 ml) 6 months and above Annually and in adverse climatic conditions like unseasonal rains and cyclones, etc. Brucellosis Bruvax Indian Immunologicals Live Brucella abortus strain 19 freeze dried bacteria, each dose ≥ 40x109 organisms 2 ml., s/c (Vial: 5 dose freeze dried vaccine with 10 ml sterile diluent) 4-8 months old serologically negative female calves Note:Only serologically negative female calves should be vaccinated with live B. abortus strain 19 while bulls and pregnant animals should not be vaccinated Depending upon prevalence in a given area, vaccination against following diseases may also be taken up Anthrax Raksha-Anthrax (Prophylactic only) Indian Immunologicals Suspension of live spores of attenuated non-capsulated strain of B. anthracis in 50% glycerinated saline, each dose ≥ 1x108 viable spores 1 ml, i/m or s/c (Vial: 50 ml) one month before grazing season or prior to the time the disease usually occurs Note: Protect animals from overexertion 3 days following vaccination. Do not vaccinate the animal 60 days before slaughter Sterne Vaccine Institute of Veterinary Preventive Medicine, Tamil Nadu **Live spores of highly antigenic nonencapsulated avirulent Sterne strain (34 F2) of B. anthracis in glycerine saline 1 ml, s/c Approx. 4 weeks prior to the time the disease usually appears Revaccinate after 2-3 weeks in heavily contaminated areas annual vaccination in endemic areas Note: Use boiled milk from lactating animals up to 1 month after vaccination, do not vaccinate within 42 days before slaughter, do not give antibiotics to animals being vaccinated; burn, autoclave or chemically disinfect container and all unused contents; adrenalin should be administered immediately if anaphylactoid reaction occurs, immunity 6m-1year Rabies Raksharab, Prophylactic Indian Immunologicals ***Tissue culture rabies virus, CVS strain adjuvanted with Al(OH)3 adjuvant, antigen potency >2.5 IU/ml 1 ml by s/c or i/m route (Vial: 1 ml, 5 ml, 10 ml) 3 m and above In case primary vaccination is given below 3 months of age, a booster dose should be given at 3 months age 3 years, annual vaccination recommended in endemic areas Post-exposure therapy (PET) I-Day Zero of dog bite or within 24 hrs, II-Day 3, III-Day 7, IV-Day 14, V- Day 28 and VI-Day 90 Note: Vaccinate only healthy animals; malnutrition, helminth infestation, administration of immunosuppressive agents like corticosteroids, radiation therapy, etc. will suppress immune response to vaccine; generally no adverse reactions are noticed, occasionally a transient, palpable nodule may occur at the site of injection; in rare cases hypersensitivity may occur, immediate treatment with antihistaminics is advocated. Points to be noted Animals should be in good health at the time of vaccination. Do not vaccinate animals which are already in stress (Like bad weather, Scarcity of fodder & water, Disease outbreaks, after transportation etc.) Try to deworm animals & remove ecto-parasites one to two weeks prior to vaccination. Strictly follow vaccination schedule after consultation with veterinary experts. Keep records of vaccination for name of vaccine manufacturing company, Batch number, Expiry date, Dose & route of vaccine. Maintain cold chain for vaccines which may have to keep for 2-8 degree Celsius temperature. Create stress free environment for animals after vaccination. Source : Buffalopedia